Literally means: Take it up the ass.
vaffanculo!
de Gtwy 26 octobre 2003
the phrase "vaffanculo" means "to go fuck yourself". the word "va" means 'go" and fanculo means "fuck you" or "fuck off" so when you put them together it means "go fuck yourself" Many times the Italian hand gesture to complement this word is a straight hand swiftly raised past their ear or it can also resemble a bitch slap.
"hey, so what do you think about the Italian National soccer team after finishing last in their group in the 2010 World Cup in Africa?"

"ma vaffanculo"
de Uleek Midiiq 16 août 2010
To cure someone of using the word "Fuck." Most use the word as in insult, although Va Fa Napoli is much more effective.
Whenever I drop F-bomb on unsuspecting strangers, I cure myself by saying the word Vaffanculo.
de Play_Crack_The_Sky 16 mars 2013
fuck off in italian
vaffanculo puta!!!!
de Big B 27 mai 2003

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