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1.
Something that is sweet, almost to the point of being sickeningly so. As a derogatory descriptive, it means something that is affectedly dainty or quaint, or is way too sentimental.

In American English it often refers to a type of simple sweet pop music, but in British English it is used much more widely for things that are nauseatingly cute or precious. It comes from the way the word sweet sounds when said in baby talk.
Belle and Sebastian are the Beatles of twee.
de urbandicfan 3 septembre 2003
 
2.
to be obnoxiously sweet, or quaint. It comes across as being disingenuous, corny, or effeminate.
This guy was walking his poodle down the street. he had this sickly twee voice when he talked to his dog. he was like; "who's my little poo poo, yes, your my little poo poo. your my little birthday boy, yes you are."
de big_bones 11 février 2010
 
3.
A singular noun referring the buttocks or ass. Also may be used as a verb, meaning to stick your butt out.

Org: Homestar Runner's Strong Bad Email 147
n: "Strongbad, you're a horse's twees."

v: "OK everybody now twees it out!"
de racartier 9 mars 2006
 
4.
the opposite of simple, authentic and true: desperately exquisite, contrived to the point of ridiculousness, trying to so hard to be ornately exceptional that you (inadvertently) end up looking like a clown. A good example is mega-artist Matthew Barney, whose films are so self-involved and obscurely referential that they seem about to burst and disappear in a multidimensional clench. His wife Bjork also fits the frame (yes she does). Most runway fashion show pieces are also a fine demonstration of the palace of twee: preening to the most self-absorbed and aloof of the lot, completely devoid of true passion. Most "artist statements" in today's art world are also laughably twee: buzzwords and effete constipated embellishments over nothing at all. Also can mean overplayed cloying sentimentalism, artificial exaggeration of feeling, grandstanding epicness, narcissistic saturation. See again Bjork.
Evanescence (pop band) are so goddamned twee, like sucking on a lollipop made of pure nutrasweet, god I wish an elevator would fall on her throat.
de schnoidl 8 octobre 2011
 
5.
The noise a sparrow makes the moment it dies.
Tweet, tweet, tweet, tweet, twee.
de AThousandCuts 8 novembre 2009
 
6.
Something that is cute ironically, with the irony taken out
The opening band wore all pink and danced joyfully, but the headlining band was even MORE twee!
de Susanarusan 1 décembre 2007
 
7.
A hybrid of the words "tiny" and "wee" used to describe states of smallness.
"That twee bastard stole my hot dog!!!"

"Girl A: I hope your boyfriend dies of rectal cancer!!!!

(silence)

Girl A: Too much?

Girl B: A twee bit."
de Little Darling 3 janvier 2010