The classiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
de illicit_fun_owns 9 septembre 2009
The (obviously) most classy way of politely telling someone that they are wrong. Take it from Joe.
Obama: I like pie.

Joe: YOU LIE!
de jazjaz130 11 septembre 2009
What Michelangelo shouted at Shredder when Shredder claims that Splinter is dead.
"You lie!"

"Do I?"
de jorgorthebarbarian 10 septembre 2009
The easiest way to object to a statement for which you have no legitimate argument.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
de stating the obvious 13 septembre 2009
What Leonardo shouted at Shredder when Shredder claimed that Splinter was dead.
Raphael: Where's Splinter?

Shredder: Ah, the rat. So it has a name. It had a name.

Leonardo: You lie!

Example 2:

jorgorthebarbarian: "You lie!" is what Michaelangelo shouted at Shredder when he claimed that Splinter was dead.

Me: You lie!
de shouldn't have apologized wuss 27 septembre 2009
The douchiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
de NightRaven 12 septembre 2009
You lie? Is a short way to say "Are you lying?" or "Are you serious" Basically those. It is used when someone says something absolutely ridiculous and you think they are lying like the example below.
Bre--I'm related to Beyonce!
Jess--NO way!!
Bre--Yup! She's my half aunt!
Jess--You Lie?
Bre--Nope! It's the truth!
de Miss Crayzee 22 mai 2009

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