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2.
A slang term for a grandfather. Used in many southern states, including Texas, Arkansas, Georgia, and Louisiana.
"Hey Pepa! Where you goin'?"

"I'm headin' back into the house to get your Mema."
de texarkanaborn 2 novembre 2012
 
1.
In Mexico: its one of several slang terms used for a girl's pussy a.k.a. vagina.

En Mexico es una palabra conocida como la chocha de una mujer.. alias Vagina.
1. She said her pepa gets wet when she gets aroused.

2. Ella dice que se le moja la pepa cuando se excita.
de chocu 28 novembre 2006
 
3.
In Colombia: A person whose intelligence is above the average.
Someone characterized for being smarter than others.
Carlos es el mas pepa de la clase.
de Mario F Monsalve 12 décembre 2005
 
4.
A nickname for someone's grandfather.
Me: "Aunt Maria, have you seen Pepa?"

Aunt Maria: "Yeah, he went out with Mema."
de CrystellaMarie 23 octobre 2008